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The National Amyloidosis Centre developed this website as a public service to provide patients and their family and friends with a comprehensive, accurate and up to date resource on all types of amyloidosis. We welcome your feedback.

Much information about amyloidosis is available on the internet.  Some of it is alarming and much of it can be confusing.  There are many different types of amyloidosis. Each type has different causes, different symptoms and different treatments.  In order to understand the disease you need to understand which type is present.

We suggest that first time visitors to this website start by reading the essentials section, then read the section about the type of amyloidosis that you or your relative has. The different types include AL ,  ATTR (which may be either hereditary or non-hereditary), AA and other, rarer hereditary types. All of these may be “systemic” which means that they affect many different parts of the body. Amyloidosis may also be “local” or “localised” which means that just a single organ or part of the body is affected. Local amyloidosis is usually of AL type and is a very different disease to systemic amyloidosis. Local amyloidosis may require no treatment or may be completely curable.

Although there is no cure for systemic amyloidosis at present there are several treatments which can be extremely helpful and prolong life for many years.  If you have been diagnosed with amyloidosis, or if a family member or friend has the condition, we hope that you will find all the information you need here.  The website is here to help you no matter what your stage of the disease.  New treatments are being researched and introduced more actively than ever before and are increasingly effective.  There are good reasons for optimism and it is important to remember that you are not alone.

Interview with Professor Sir Mark Pepys – 2018

Watch other interviews where Professor Sir Mark Pepys discusses some of his additional professional interests and achievements.

Interviews have been provided courtesy of Dr Anton Titov, Diagnostic Detectives

More about the NAC

More about Public and Patient Involvement at the NAC

Essential information

Publications authored by NAC doctors

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amyloid deposit in Afib amyloidosis congo red kidney

Kidney tissue, viewed using specialist laboratory techniques to pick up amyloid deposits (stained with Congo Red dye and viewed under cross-polarised light)
Reproduced with permission from Int J Biochem Cell Biol, Dec 2003;35:12;1608-1613

SAP structure

Structure of the serum amyloid P component (SAP) molecule, reproduced from Nature 367, 338 – 345 (27 January 1994). SAP is found in all types of amyloid deposits.

The Amyloidosis Awareness Programme of the NAC is generously supported by:
Akcea Therapeutics
Alnylam Pharmaceuticals
The Tufton Charitable Trust

General administration, web design and medical communications provided by:
Dr Miriam Vered, Vered Consulting